●He aha ka Berberine?
ʻO Berberine kahi alkaloid maoli i unuhi ʻia mai nā aʻa, nā ʻōpala a me nā ʻili o nā mea kanu like ʻole, e like me Coptis chinensis, Phellodendron amurense a me Berberis vulgaris. ʻO ia ka mea hana nui o Coptis chinensis no ka hopena antibacterial.
ʻO Berberine kahi aniani melemele me ka ʻono ʻawaʻawa. ʻO ka mea ʻawaʻawa nui ma Coptis chinensis ka berberine hydrochloride. He isoquinoline alkaloid kēia i hoʻolaha ʻia i loko o nā mea kanu kūlohelohe. Aia ia ma Coptis chinensis ma ke ʻano o ka hydrochloride (berberine hydrochloride). Ua ʻike nā haʻawina e hiki ke hoʻohana ʻia kēia pūhui no ka mālama ʻana i nā maʻi koko, ka maʻi hepa, nā maʻi cardiovascular, hypertension, nā maʻi maʻi bacterial a me nā maʻi viral, ka maʻi maʻi, ka maʻi Alzheimer a me ka ʻāʻī.
● He aha nā pono olakino o Berberine?
1. Antioxidant
Ma lalo o nā kūlana maʻamau, mālama ke kino o ke kanaka i ke kaulike ma waena o nā antioxidants a me nā prooxidants. ʻO ke koʻikoʻi oxidative he kaʻina hana ʻino i hiki ke lilo i mea koʻikoʻi no ka hōʻino ʻana o ka hale cell, a laila e hoʻoulu ai i nā ʻano maʻi like ʻole e like me ka maʻi cardiovascular, cancer, neurological maʻi a me ka maʻi diabetes. ʻO ka hana nui ʻana o nā ʻano oxygen reactive (ROS), ka mea maʻamau ma o ka hoʻoulu nui ʻana o NADPH e nā cytokines a i ʻole ma o ke kaulahao transport electron mitochondrial a me xanthine oxidase, hiki ke alakaʻi i ke kaumaha oxidative. Ua hōʻike ʻia nā hoʻokolohua e hōʻike ana nā metabolites berberine a me ka berberine i ka hana scavenging maikaʻi loa -OH, ʻo ia ka mea like me ka potent antioxidant vitamina C. Hiki i ka mālama ʻana i ka berberine i nā ʻiole diabetic ke nānā i ka piʻi ʻana o ka hana SOD (superoxide dismutase) a me ka emi ʻana o MDA (a. hōʻailona o ka lipid peroxidation) pae [1]. Hōʻike ʻia nā hopena hou aʻe e pili pono ana ka hana scavenging o berberine me kāna hana ferrous ion chelating, a ʻo ka hui C-9 hydroxyl o berberine he ʻāpana koʻikoʻi.
2.Ai-ke koko
Ua nui nā hōʻike e pili ana i ka hopena anti-cancer oberberine. Ua hōʻike ʻia nā haʻawina like ʻole i nā makahiki i hala iho nei he koʻikoʻi nui ka berberine i ka mālama ʻana i nā maʻi maʻi maʻi koʻikoʻi e like me ka maʻi ovarian, endometrial cancer, cervical cancer, breast cancer, lung cancer, colorectal cancer, kidney cancer, bladder cancer, and prostate cancer. [2]. Hiki i ka Berberine ke pale i ka hoʻonui ʻana o nā pūnaʻi tumora ma o ka launa pū ʻana me nā ʻano pahuhopu a me nā mīkini. Hiki iā ia ke hoʻololi i ka hōʻike o nā oncogenes a me nā genes pili i ka carcinogenesis e hoʻokō i ke kumu o ka hoʻoponopono ʻana i ka hana o nā enzymes pili e kāohi ai i ka hoʻonui.
3. Hoʻohaʻahaʻa i nā lipids koko a pale i ka ʻōnaehana cardiovascular
He kuleana koʻikoʻi ʻo Berberine i ka mālama ʻana i nā maʻi cardiovascular a loaʻa i kahi ākea o nā noi. Hoʻokō ʻo Berberine i ke kumu o ka anti-arrhythmia ma o ka hōʻemi ʻana i ka ulu ʻana o ka ventricular premature beats a me ka pale ʻana i ka hanana ventricular tachycardia. ʻO ka lua, ʻo ka dyslipidemia kahi kumu pilikia nui no ka maʻi cardiovascular, i hōʻike ʻia e nā kiʻekiʻe kiʻekiʻe o ka kolamu holoʻokoʻa, triglycerides, a me ka lipoprotein cholesterol haʻahaʻa (LDL), a me ka emi ʻana o nā kiʻekiʻe o ka high-density lipoprotein (HDL), a hiki i ka berberine ke mālama ikaika i ka. paʻa o kēia mau hōʻailona. ʻO ka hyperlipidemia lōʻihi kahi kumu nui o ka hoʻokumu ʻana o ka atherosclerotic plaque. Ua hōʻike ʻia e pili ana ka berberine i nā mea loaʻa LDL i nā hepatocytes e hoʻemi i ke kiʻekiʻe o ka cholesterol serum kanaka i nā hepatocytes. ʻAʻole wale kēlā,berberinehe hopena inotropic maikaʻi a ua hoʻohana ʻia no ka mālama ʻana i ka naʻau congestive.
4. Hoʻohaʻahaʻa i ke kō koko a hoʻoponopono i ka endocrine
ʻO ka maʻi diabetes mellitus (DM) kahi maʻi metabolic i hōʻike ʻia e ke kiʻekiʻe o ke kō koko koko (hyperglycemia) ma muli o ka hiki ʻole o nā pūnaʻi B pancreatic ke hoʻohua i ka insulin, a i ʻole ka nalowale ʻana o ka pane ʻana o nā kiko kiko kūpono i ka insulin. Ua ʻike ʻia ka hopena hypoglycemic o berberine i ka makahiki 1980 i ka mālama ʻana i nā maʻi maʻi maʻi me ka maʻi maʻi.
He nui nā haʻawina i hōʻike i kēlāberberinehoʻohaʻahaʻa i ke kō koko ma o nā hana penei:
● Kāohi i ka mitochondrial glucose oxidation a hoʻoulu i ka glycolysis, a laila hoʻonui i ka metabolism glucose;
● Hoʻemi i nā pae ATP ma ke kāohi ʻana i ka hana mitochondrial i loko o ke ake;
● Kāohi i ka hana o DPP 4 (he ubiquitous serine protease), ma laila e hoʻokaʻawale ai i kekahi mau peptides e hana e hoʻonui i ka nui o ka insulin i mua o ka hyperglycemia.
● He hopena maikaʻi ka Berberine i ka hoʻomaikaʻi ʻana i ka insulin resistance a me ka hoʻohana ʻana i ka glucose i loko o nā ʻiʻo ma o ka hoʻohaʻahaʻa ʻana i nā lipids (ʻoi aku ka triglycerides) a me nā pae momona momona ʻole o ka plasma.
Hōʻuluʻulu manaʻo
I kēia mau lā,berberinehiki ke synthesized artificial a hoʻololi ʻia e nā ʻano hana ʻenehana kristal. Loaʻa iā ia ke kumukūʻai haʻahaʻa a me ka ʻenehana kiʻekiʻe. Me ka hoʻomohala ʻana o ka noiʻi olakino a me ka hohonu o ka noiʻi kemika, ʻoiaʻiʻo e hōʻike ʻo berberine i nā hopena lāʻau lapaʻau. Ma ka lima hoʻokahi, ʻaʻole i loaʻa i ka berberine nā hopena kupaianaha i ka noiʻi lāʻau lapaʻau kuʻuna i ka antibacterial, antiviral, anti-inflammatory, anti-tumor, anti-diabetic, a me ka mālama ʻana i nā maʻi cardiovascular a me ka cerebrovascular, akā ʻo kāna hoʻolālā ʻenekini aniani a me ka nānā ʻana morphological. ua loaa ka noonoo nui. Ma muli o kona koʻikoʻi koʻikoʻi a me ka haʻahaʻa haʻahaʻa a me nā hopena ʻaoʻao, loaʻa iā ia ka mana nui i ka noi lapaʻau a he ākea ākea. Me ka hoʻomohala ʻana o ka biology cell, e hoʻomaʻamaʻa ʻia ke ʻano lāʻau lapaʻau o berberine mai ka pae cellular a hiki i nā pae molecular a me nā pae kiʻekiʻe, e hāʻawi ana i ke kumu kumu no kāna noi lapaʻau.
● Hoʻolako hou ʻo NEWGREENBerberine/ Liposomal Berberine Pauka/Kapu/Papa
Ka manawa hoʻouna: Oct-28-2024
