I nā makahiki i hala iho nei,NMN, i lilo i mea kaulana ma ka honua holoʻokoʻa, ua noho i nā huli wela he nui. Pehea ka nui o kāu ʻike e pili ana iā NMN? I kēia lā, e kālele mākou i ka hoʻolauna ʻana iā NMN, i aloha ʻia e nā mea a pau.
● He ahaNMN?
Kapa ʻia ʻo NMN he β-Nicotinamide Mononucleotide, a i ʻole NMN no ka pōkole. Loaʻa iā NMN ʻelua diastereomers: α a me β. Ua ʻike nā haʻawina ʻo ka β-type NMN wale nō ka hana olaola. Ma ke ʻano, ua haku ʻia ka mole me ka nicotinamide, ribose, a me ka phosphate.
ʻO NMN kekahi o nā mea mua o NAD +. I nā huaʻōlelo ʻē aʻe, loaʻa ka hopena koʻikoʻi o NMN ma o ka hoʻololi ʻana i NAD +. I ko mākou mau makahiki, e emi mālie ka pae o NAD + i ke kino o ke kanaka.
I ka 2018 Aging Biology Research Compilation, ua hōʻuluʻulu ʻia ʻelua mau ʻano kumu o ka ʻelemakule kanaka:
1. Poino ma muli o ke koʻikoʻi oxidative (hōʻike ʻia nā hōʻailona e like me nā maʻi like ʻole)
2. Ua emi iho nā pae o NAD+ i loko o nā pūnaewele
Ke kākoʻo nei ka nui o nā hoʻokō hoʻonaʻauao ma NAD+ anti-aging noiʻi e nā ʻepekema kiʻekiʻe o ka honua i ka hopena o ka hoʻonui ʻana i nā pae NAD+ hiki ke hoʻomaikaʻi i ka maikaʻi o ke olakino ma nā ʻano he nui a hoʻopaneʻe i ka ʻelemakule.
● He aha nā pono olakino oNMN?
1. Hoʻonui i ka ʻike NAD +
ʻO NAD + kahi mea nui no ka mālama ʻana i ka hana o ke kino. Aia ia i loko o nā pūnaewele a pau a komo i nā kaukani o nā hopena physiological i loko o ke kino. ʻOi aku ma mua o 500 mau enzyme i loko o ke kino kanaka e koi iā NAD +.
Mai ke kiʻi, hiki iā mākou ke ʻike i nā pōmaikaʻi o ka hoʻonui ʻana i ka NAD + i nā ʻano ʻano like ʻole e hoʻomaikaʻi i ke olakino o ka lolo a me ka ʻōnaehana nerve, ate a me nā kīʻaha, nā kīʻaha koko, ka puʻuwai, ka ʻiʻo lymphatic, nā ʻāpana hānau, pancreas, adipose tissue, a me nā ʻiʻo.
Ma 2013, ua hōʻike ʻia kahi hui noiʻi i alakaʻi ʻia e Professor David Sinclair o ke Kula Lapaʻau ʻo Harvard ma o nā hoʻokolohua ma hope o ka hoʻokō waha ʻana o NMN no hoʻokahi pule, ua hoʻonui ʻia ka pae NAD + i nā ʻiole 22 mau mahina, a me nā hōʻailona biochemical nui e pili ana i ka homeostasis mitochondrial a. Ua hoʻihoʻi ʻia ka hana ʻiʻo i ke kūlana o nā ʻiole ʻōpio e like me 6 mau mahina.
2. Ho'ā i nā protein SIR
Ua ʻike ʻia ka noiʻi ʻana i nā makahiki he 20 i hala iho nei he kuleana koʻikoʻi ʻo Sirtuins i ka hana o nā cell cell āpau, e pili ana i nā kaʻina physiological e like me ka mumū, ka ulu ʻana o ka cell, ka circadian rhythm, ka metabolism ikehu, ka hana neuronal a me ke kūpaʻa koʻikoʻi.
Ua kapa pinepine ʻia ʻo Sirtuins i ka ʻohana protein longevity, kahi ʻohana o NAD + -dependent deacetylase proteins.
I ka makahiki 2019, ua ʻike ʻo Polofesa Kane AE o ke Keʻena Genetics ma Harvard Medical School a me nā mea ʻē aʻeNMNhe mea nui ia no ka synthesis o NAD + i ke kino. Ma hope o ka hoʻonui ʻana o NMN i ke kiʻekiʻe o NAD + i loko o nā cell, ʻoi aku ka nui o kāna mau hopena maikaʻi (e like me ka hoʻomaikaʻi ʻana i ka metabolism, pale ʻana i ka ʻōnaehana cardiovascular, a me nā mea ʻē aʻe) e hoʻokō ʻia ma ka hoʻoulu ʻana iā Sirtuins.
3. Hoʻoponopono i ka pōʻino DNA
i ka hoʻopili ʻana i ka hana a Sirtuins, ʻo ke kiʻekiʻe o ka NAD + i loko o ke kino he substrate koʻikoʻi no ka DNA repair enzyme PARPs (poly ADP-ribose polymerase).
4. Hoʻoikaika i ka metabolism
ʻO ka Metabolism kahi hōʻiliʻili o nā hopena kemika e mālama i ke ola i loko o nā mea ola, e ʻae iā lākou e ulu a hānau hou, mālama i ko lākou ʻano, a pane i ke kaiapuni. ʻO ka Metabolism kahi hana e hoʻololi mau ai nā meaola i nā mea a me ka ikehu. Ke pau ia, pau ke ola o ke kino. Ua ʻike ʻo Polofesa Anthony o ke Kulanui o Kaleponi a me kāna hui ua lilo ʻo NAD + metabolism i mea lapaʻau kūpono no ka hoʻomaikaʻi ʻana i nā maʻi pili i ka ʻelemakule a me ka hoʻonui ʻana i ke olakino kanaka a me ke ola.
5. Hoʻoikaika i ka hoʻoponopono hou ʻana o ka moku koko a mālama i ka elasticity moku koko
He ʻiʻo koʻikoʻi nā kīʻaha koko no ka lawe ʻana i ka oxygen a me nā meaʻai, ka hana ʻana i ka carbon dioxide a me nā metabolites, a me ka hoʻoponopono ʻana i ka mahana o ke kino. I ko mākou mau makahiki, e nalowale ana nā kīʻaha koko i ko lākou maʻalahi, lilo i paʻakikī, mānoanoa, a haiki, e hoʻoulu ai i ka "arteriosclerosis."
Ma 2020, kahi noiʻi e kekahi mau haumāna PhD mai Zhejiang University of Technology ma Kina, me Sh, ʻike ʻia ma hope o ka lawelawe wahaNMNi nā ʻiole kaumaha, ua hoʻopau ʻia nā hōʻailona o ke kaumaha ma o ka hoʻonui ʻana i nā pae NAD +, ka hoʻoulu ʻana iā Sirtuin 3, a me ka hoʻomaikaʻi ʻana i ka ikehu mitochondrial metabolism i loko o ka hippocampus a me nā pūnaʻi ate o ka lolo o nā ʻiole.
6. Mālama i ke ola o ka naʻau
ʻO ka puʻuwai ka mea nui i loko o ke kino o ke kanaka a he mea nui ia no ka mālama ʻana i ka hana naʻau. ʻO ka emi ʻana o nā pae NAD + e pili ana i ka pathogenesis o nā maʻi cardiovascular. Ua hōʻike pū ʻia kekahi helu nui o nā haʻawina maʻamau i ka hoʻohui ʻana i ka coenzyme hiki iaʻu ke pōmaikaʻi i nā hiʻohiʻona maʻi puʻuwai.
7. E mālama i ke olakino lolo
Hiki i ka neurovascular dysfunction ke hana i ka pōʻino o ka naʻau a me ka neurodegenerative cognitive. He mea nui ka mālama ʻana i ka hana neurovascular no ka pale ʻana i nā maʻi neurodegenerative.
ʻO nā mea pilikia e like me ka maʻi maʻi, ke kiʻekiʻe o ke ola waena, ka momona o ka waena, ka hana ʻole o ke kino a me ka puhi paka e pili pū ana me ka dementia vascular a me ka maʻi Alzheimer.
8. Hoʻonui i ka ʻike insulin
Hōʻike ka ʻike insulin i ke kiʻekiʻe o ka pale ʻana i ka insulin. ʻO ka haʻahaʻa o ka naʻau o ka insulin, ʻoi aku ka haʻahaʻa o ka haki ʻana o ke kō.
ʻO ke kūpaʻa ʻana o ka insulin e pili ana i ka emi ʻana o ka naʻau o nā mea i manaʻo ʻia o ka insulin i ka hana o ka insulin, ʻo ia hoʻi, kahi mokuʻāina kahi e hoʻohua ai kahi maʻi maʻamau o ka insulin i kahi haʻahaʻa haʻahaʻa ma mua o ka hopena biological maʻamau. ʻO ke kumu nui o ka maʻi maʻi type 2 ʻo ka haʻahaʻa haʻahaʻa o ka insulin a me ka haʻahaʻa o ka insulin.
NMN, ma ke ʻano he mea hoʻohui, hiki ke kōkua i ka hoʻomaikaʻi ʻana i ka ʻike insulin ma o ka hoʻonui ʻana i nā pae NAD +, hoʻoponopono i nā ala metabolic, a me ka hoʻomaikaʻi ʻana i ka hana mitochondrial.
9. Kōkua me ka mālama kaumaha
ʻAʻole pili wale ke kaumaha i ka maikaʻi o ke ola a me ke olakino, akā lilo pū kekahi i mea hoʻoulu no nā maʻi maʻi ʻē aʻe. Ua hōʻike nā haʻawina e hiki i ka NAD precursor β-nicotinamide mononucleotide (NMN) ke hoʻohuli i kekahi o nā hopena maikaʻi ʻole o ka meaʻai momona momona (HFD).
I ka makahiki 2017, ua hoʻohālikelike ʻo Polofesa David Sinclair o ke Kula Lapaʻau ʻo Harvard a me kahi hui noiʻi mai ke Kula Lapaʻau Australian i hoʻohālikelike ʻia i nā ʻiole wahine momona i hoʻomaʻamaʻa ʻia ma ka papa hana no 9 mau pule a i ʻole ʻia me ka NMN i kēlā me kēia lā no 18 mau lā. Ua hōʻike ʻia nā hopena ua ʻoi aku ka ikaika o ka NMN i ka metabolism momona a me ka synthesis ma mua o ka hoʻoikaika kino.
● Palekana oNMN
Manaʻo ʻia ʻo NMN he palekana i nā hoʻokolohua holoholona, a he mea paipai nā hopena. Ua hoʻomaka ʻia he 19 mau hoʻokolohua lapaʻau kanaka, a he 2 i hoʻopuka i nā hopena hoʻokolohua.
Ua paʻi kekahi hui noiʻi mai Washington University School of Medicine ma St. Louis i kahi ʻatikala ma ka puke moʻolelo ʻepekema kiʻekiʻe "Science", e hōʻike ana i nā hopena o ka hoʻokolohua hoʻokolohua kanaka mua o ka honua, e hōʻoia ana i nā pono metabolic o NMN ma ke kino kanaka.
●NEWGREEN Hoʻolako NMN Pauka/Kapu/Liposomal NMN
Ka manawa hoʻouna: Oct-15-2024
