• He aha iaTetrahydrocurcumin ?
ʻO Rhizoma Curcumae Longae ka rhizoma maloʻo o Curcumae Longae L. Hoʻohana nui ʻia ʻo ia ma ke ʻano he meaʻai a me ke ʻala. ʻO ka hui kemika ka nui o ka curcumin a me ka ʻaila volatile, ʻokoʻa nā saccharides a me nā sterols. Ua hōʻike ʻia ʻo Curcumin (CUR), ma ke ʻano he polyphenol maoli i loko o ka mea kanu curcuma, ua loaʻa nā hopena pharmacological like ʻole, me ka anti-inflammatory, antioxidant, oxygen free radical elimination, pale ate, anti-fibrosis, anti-tumor hana a me ka pale. o ka maʻi o Alzheimer (AD).
Hoʻopili koke ʻia ka Curcumin i loko o ke kino i loko o ka conjugates glucuronic acid, conjugates sulfuric acid, dihydrocurcumin, tetrahydrocurcumin, a me hexahydrocurcumin, a laila hoʻololi ʻia i tetrahydrocurcumin. Ua hōʻoia nā haʻawina hoʻokolohua he maikaʻi ʻole ke kūpaʻa o ka curcumin (e ʻike i ka photodecomposition), maikaʻi ʻole ka wai a me ka bioavailability haʻahaʻa. No laila, ʻo kāna ʻāpana metabolic koʻikoʻi tetrahydrocurcumin i loko o ke kino ua lilo i wahi wela noiʻi ma ka home a ma waho i nā makahiki i hala.
Tetrahydrocurcumin(THC), ʻo ia ka metabolite ikaika loa a me ka nui o ka curcumin i hana ʻia i ka wā o kāna metabolism in vivo, hiki ke hoʻokaʻawale ʻia mai ka cytoplasm o ka ʻōpū liʻiliʻi a me ka ate ma hope o ka hoʻokele curcumin i ke kanaka a i ʻole ka ʻiole. ʻO ka molecular formula C21H26O6, ʻo ke kaumaha molecular he 372.2, ʻo ka density he 1.222, a ʻo ka helu heheʻe he 95 ℃-97 ℃.
• He aha nā pōmaikaʻi oTetrahydrocurcuminMa ka mālama ʻili?
1. Ka hopena i ka hana melanin
Hiki i ka Tetrahydrocurcumin ke ho'ēmi i ka melanin i loko o nā pūnaewele B16F10. I ka hāʻawi ʻia ʻana o nā kikoʻī like o ka tetrahydrocurcumin (25, 50, 100, 200μmol / L), ua emi ka melanin mai 100% a i 74.34%, 80.14%, 34.37%, 21.40%.
Hiki i ka Tetrahydrocurcumin ke kaohi i ka hana tyrosinase ma nā keena B16F10. I ka hāʻawi ʻia ʻana o ka manaʻo kūpono o ka tetrahydrocurcumin (100 a me 200μmol / L) i nā cell, ua emi ka hana tyrosinase intracellular i 84.51% a me 83.38%, kēlā me kēia.
2. Anti-photoaging
E ʻoluʻolu e ʻike i ke kiʻi ʻiole ma lalo nei: Ctrl (control), UV (UVA + UVB), THC (UVA + UVB + THC THC100 mg/kg, hoʻoheheʻe ʻia i loko o 0.5% sodium carboxymethyl cellulose). Nā kiʻi o ka ʻili ma ke kua o nā ʻiole KM ma 10 mau pule ma hope o ka mālama ʻana i ka THC a me ka irradiation UVA. Ua loiloi ʻia nā hui like ʻole me ka UVA flux radiation i ka ʻelemakule māmā e ka helu Bissett. ʻO nā koina i hōʻike ʻia ʻo ia ka mean standard deviation (N = 12/ pūʻulu). *P<0.05, **P
Mai ka hiʻohiʻona, i hoʻohālikelike ʻia me ka pūʻulu hoʻomalu maʻamau, ʻo ka ʻili o ka pūʻulu hoʻokele kumu hoʻohālike, ʻike ʻia ka erythema, ulceration, hohonu a mānoanoa nā wrinkles, hele pū ʻia me nā hoʻololi ʻili, e hōʻike ana i kahi hanana photoaging maʻamau. Hoʻohālikelike ʻia me ka pūʻulu hoʻomalu kükohu, ka degere poino otetrahydrocurcuminʻO 100 mg / kg pūʻulu he haʻahaʻa loa ia ma mua o ka hui hoʻomalu kumu hoʻohālike, a ʻaʻohe scab a me erythema i ʻike ʻia ma ka ʻili, ʻike ʻia ka pigmentation liʻiliʻi a me nā wrinkles maikaʻi.
3. ʻO ka antioxidant
Hiki i ka Tetrahydrocurcumin ke hoʻonui i ka pae SOD, hoʻemi i ka pae LDH a hoʻonui i ka pae GSH-PX i nā cell HaCaT.
Hoʻopau i nā radical manuahi DPPH
ʻO katetrahydrocurcuminUa hoʻoheheʻe ʻia ka hopena e 10, 50, 80, 100, 200, 400, 800, 1600 mau manawa, a ua hui pū ʻia ka hāpana hāpana me 0.1mmol/L DPPH solution ma ka ratio o 1:5. Ma hope o ka hopena ma ka lumi wela no 30min, ua hoʻoholo ʻia ka waiwai absorbance ma 517nm. Hōʻike ʻia ka hopena ma ke kiʻi:
4. Kāohi i ka ʻili ʻili
Ua hōʻike ʻia ka haʻawina hoʻokolohua ua mālama mau ʻia ka ho'ōla ʻana o nā ʻiole no 14 mau lā, i ka wā i hoʻohana ʻia ai ka gel THC-SLNS i kēlā me kēia, ʻoi aku ka wikiwiki a me ka maikaʻi o ka hoʻōla ʻana i ka ʻeha a me ka hopena o THC a me ka mana maikaʻi, ʻo ka iho ʻana ʻo THC-SLNS gel. >
THC >He mana maikaʻi.
Aia ma lalo iho nā kiʻi hōʻike o ka ʻiole hōʻeha ʻeha a me nā nānā histopathological, A1 a me A6 e hōʻike ana i ka ʻili maʻamau, A2 a me A7 e hōʻike ana i ka THC SLN gel, A3 a me A8 e hōʻike ana i nā mana maikaʻi, A4 a me A9 e hōʻike ana i ka THC gel, a me A5 a me A10 e hōʻike ana i ka paʻa paʻa. lipid nanoparticles (SLN), kēlā me kēia.
• Noi oTetrahydrocurcuminI loko o nā mea hoʻonani
1. Nā huahana mālama ʻili:
Nā mea kūʻē i ka wā kahiko:Hoʻohana ʻia i nā ʻaila anti-kahiko a me nā serum e kōkua i ka hōʻemi ʻana i nā wrinkles a me nā laina maikaʻi a hoʻomaikaʻi i ka elasticity ʻili.
Nā huahana keʻokeʻo:Hoʻohui ʻia i nā essences keʻokeʻo a me nā creams e kōkua i ka hoʻomaikaʻi ʻana i ka ʻili ʻole a me nā kiko.
2.Ati-inflammatory huahana:
Hoʻohana ʻia i nā huahana mālama ʻili koʻikoʻi e like me ka ʻoluʻolu a me ka hoʻoponopono ʻana i nā creams e hōʻemi i ka ʻulaʻula a me ka huhū.
3. Cleaning Products:
Hoʻohui i nā mea hoʻomaʻemaʻe a me nā exfoliants e kōkua i ka hoʻomaʻemaʻe ʻana i ka ʻili a hāʻawi i nā pono antibacterial e pale ai i ka haki.
4. Nā huahana pale lā:
Hana ʻo ia ma ke ʻano he antioxidant e hoʻomaikaʻi i ka pono o ka sunscreen a pale i ka ʻili mai nā kukuna UV.
5. Maka maka:
Hoʻohana ʻia i loko o nā maka maka like ʻole e hāʻawi i ka meaʻai hohonu a me ka hoʻoponopono ʻana, e hoʻomaikaʻi i ke ʻano o ka ʻili.
Tetrahydrocurcuminhoʻohana nui ʻia i nā mea hoʻonaninani, uhi i ka mālama ʻili, hoʻomaʻemaʻe, pale i ka lā a me nā māla ʻē aʻe. Ua makemake ʻia no kāna mau antioxidant, anti-inflammatory a me nā hopena keʻokeʻo.
Ka manawa hoʻouna: Oct-10-2024
